Anales de Lípidos en Biología y Medicina
Número 69, 14 de Febrero de 2010
Contenido adicional
Noticias
- LIPIDS: -Regular exercise training prevents aortic valve disease in low-density lipoprotein–receptor–deficient mice
Background Regular exercise training (ET) slows the progression of atherosclerotic lesions, reduces oxidative stress, and increases nitric oxide bioavailability, all of which may be expected to ...
- LIPIDS: -Association of statin prescription with small abdominal aortic aneurysm progression
Background Statins have been suggested to reduce expansion of abdominal aortic aneurysms (AAAs) independent of lipid-lowering effects.Methods We assessed the association of statin treatment and ...
- LIPIDS: -The National Niemann-Pick Type C1 Disease Database: correlation of lipid profiles, mutations, and biochemical phenotypes
Niemann-Pick type C1 disease (NPC1) is an autosomal recessive lysosomal storage disorder characterized by neonatal jaundice, hepatosplenomegaly, and progressive neurodegeneration. The present study ...
- FULLTEXT: -LIPIDS: -Assessing the efficacy of protein farnesyltransferase inhibitors in mouse models of progeria
Hutchinson-Gilford progeria syndrome (HGPS) is caused by the accumulation of a farnesylated form of prelamin A (progerin). Previously, we showed that blocking protein farnesylation with a ...
- LIPIDS: -Acidic retinoids synergize with vitamin A to enhance retinol uptake and STRA6, LRAT, and CYP26B1 expression in neonatal lung
Vitamin A (VA) is essential for fetal lung development and postnatal lung maturation. VA is stored mainly as retinyl esters (REs), which may be mobilized for production of retinoic acid (RA). This ...
- LIPIDS: -Prevention of high-fat diet-induced muscular lipid accumulation in rats by lipoic acid is not mediated by AMPK activation[S]
Skeletal muscle triglyceride accumulation is associated with insulin resistance in obesity. Recently, it has been suggested that lipoic acid (ALA) improves insulin sensitivity by lowering ...
- LIPIDS & VORICONAZOL & BRAIN CHOLESTEROL: -The antifungal drug voriconazole is an efficient inhibitor of brain cholesterol 24S-hydroxylase in vitro and in vivo
Cholesterol 24S-hydroxylase (CYP46A1) is of key importance for cholesterol homeostasis in the brain. This enzyme seems to be resistant toward most regulatory factors and at present no drug effects on ...
- LIPIDS: -New cholesterol-specific antibodies remodel HIV-1 target cells’ surface and inhibit their in vitro virus production
The importance of membrane rafts in HIV-1 infection is still in the focus of interest. Here, we report that new monoclonal anticholesterol IgG antibodies (ACHAs), recognizing clustered membrane ...
- FULTEXTO: -LÍPIDOS Y ATEROESCLEROSIS: -La gestión de una sociedad científica (II). Un plan estratégico para la SEA
Una de las características de una sociedad científica es ofrecer servicios de distinta índole: científicos, personales para los socios, para el desarrollo profesional de sus miembros, etc. El equipo ...
- FULTEXTO: -MEDICINA VASCULAR & ENDOTELIO: -La hipoxia induce la expresión de la lisil oxidasa (LOX) en células endoteliales
Introducción. La hipoxia participa en el desarrollo de enfermedades cardiovasculares por la regulación coordinada de múltiples genes, incluidos aquellos implicados en la síntesis/ reparación de ...
- LIPIDS: -Rapid quantification of conjugated and unconjugated bile acids and C27 precursors in dried blood spots and small volumes of serum
The aim of the study was to develop a method for fast und reliable diagnosis of peroxisomal diseases and to facilitate differential diagnosis of cholestatic hepatopathy. For the quantification of ...
- LIPIDS: -Enzymatic assessment of cholesterol on electrophoresis gels for estimating HDL size distribution and plasma concentrations of HDL subclasses
Background. The aim of this study was to develop an enzymatic cholesterol staining method to determine HDL subclasses in a polyacrylamide gradient gel electrophoresis, which further allows staining ...
- LIPIDS: -Western diet changes cardiac acyl-CoA composition in obese rats: A potential role for hepatic lipogenesis
The lipotoxic footprint of cardiac maladaptation in diet-induced obesity is poorly defined. We investigated how manipulation of dietary lipid and carbohydrate influenced potential lipotoxic species ...
- LIPIDS: -TNF-alpha decreases ABCA1 expression and attenuates HDL cholesterol efflux in the human intestinal cell line, Caco-2
HDL cholesterol levels are decreased in Crohns disease, a TNF-alpha driven chronic inflammatory condition involving the gastrointestinal tract. ABCA1, one of several LXR target genes, is a cell ...
- LIPIDS: -Regulating survival and development in the retina: key roles for simple sphingolipids
Many sphingolipids have key functions in the regulation of crucial cellular processes. Ceramide (Cer) and sphingosine (Sph) induce growth arrest and cell death in multiple situations of cellular ...
