SUMMARY & CONTEXT Perceptual closure is the ability to identify objects based on partial information and depends on the function of a distributed network of brain regions that include the ...

Context  Most of what we know about antipsychotic drug effects is at the receptor level, distal from the neural system effects that mediate their clinical efficacy. Studying ...

Context  The neural abnormalities underlying genetic risk for bipolar disorder, a severe, common, and highly heritable psychiatric condition, are largely unknown. An opportunity to define ...

 Fundamento El inicio lento de acción de los antidepresivos y la elevada proporción de pacientes con una respuesta insuficiente, o no respondedores, son retos clínicos ...

Context  Prenatal smoking exposure modulates brain development, which may deviate mental development of the offspring. Objective  To study the effects of prenatal smoking ...

Objective: Borderline personality disorder is characterized by a lack of effective regulation of emotional responses. The authors investigated the role of the endogenous opioid system and ...

Objective: Posttraumatic stress disorder (PTSD) related to childhood abuse is associated with features of affect regulation and interpersonal disturbances that substantially contribute to ...

  Context  Collaborative care interventions for depression in primary care settings are clinically beneficial and cost-effective. Most prior studies were conducted in urban settings. ...

The number of people with dementia has increased dramatically with global ageing. Nevertheless, the pathogeneses of these diseases are not sufficiently understood. The present study aims to analyse ...

Context  Whether obsessive-compulsive disorder (OCD) is adequately classified as an anxiety disorder is a matter of considerable debate. Objectives  To quantitatively compare ...

Resumen & Introducción: Los trastornos límite de personalidad se caracterizan por una elevada impulsividad y agresividad. Las conductas agresivas e impulsivas se han ...

Objective: Prospective long-term studies of risk factors for suicide attempts among patients with major depressive disorder have not investigated the course of illness and state at the time ...

Objective: Several lines of evidence suggest that antipsychotic drug efficacy is mediated by dopamine type 2 (D2) receptor blockade. Therefore, it seems plausible that variation in the ...

Objective: recent meta-analysis identified processing speed inefficiency as the largest single cognitive impairment in schizophrenia. However, the effect of potential moderator variables, ...

Resumen La neurregulina 1 (NRG1) y su receptor, ErbB4, se han implicado en la esquizofrenia tanto a nivel genético como de transcripción. En la presente investigación se ...